Big data plays an increasingly important role in today’s practice of otolaryngology and in all of healthcare. In Big Data in Otolaryngology, Dr. Jennifer Villwock leads a team of expert authors who provide a comprehensive view of many key impacts of big data in otolaryngology—including understanding what big data is and what we can and cannot learn from it; best practices regarding analysis; translating findings to clinical care and associated cautions; ethical issues; and future directions.