This book offers a wide-ranging overview of the state of the art in radioguided surgery, covering methodological aspects, current clinical applications, and the latest innovations. The clinical chapters describe and assess the techniques applicable in respect of a wide range of malignancies, including but not limited to breast cancer, melanoma and other cutaneous malignancies, gynecologic tumors, head and neck malignancies, thyroid cancer, urologic malignancies, colon cancer, gastroesophageal cancer, lung cancer, bone tumors, parathyroid adenomas, and neuroendocrine tumors. Sample cases are presented and accompanying videos facilitate understanding of the described procedures. The section on methodology provides up-to-date information on gamma probes, PET probes, gamma cameras, radionuclides, and radiopharmaceuticals, 3D imaging, image fusion, navigation, and dosimetry. In addition, new technical developments and their translation into clinical practice are extensively reviewed. The authors are all expert imaging specialists and clinicians who offer a multidisciplinary approach, ensuring that the book will hold wide appeal for surgical oncologists and surgeons, nuclear medicine physicians and technologists, and trainees.