Fluorescence-Guided Neurosurgery

Advances in fluorescence-guided surgery (FGS) have resulted in a paradigm shift in neurosurgical
approaches to neuro-oncological and cerebrovascular pathologies. Edited by two of the foremost
authorities on the topic, Fluorescence-Guided Neurosurgery: Neuro-oncology and Cerebrovascular
Applications encompasses the depth and breadth of this groundbreaking, still nascent technology.
The book reflects significant contributions made by world renowned neurosurgeons Constantinos
Hadjipanayis, Walter Stummer, and esteemed contributors on the growing uses of 5-aminolevulinic
acid (5-ALA) and other FGS agents.
The European Medicine Agency approved 5-ALA in 2007, heralding the birth of FGS globally. In 2017,
the U.S. Food and Drug Administration approved 5-ALA (Gleolan) as an imaging agent to facilitate
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realtime detection and visualization of malignant tissue during glioma surgery. In the two decades
since Dr. Stummer's initial description of 5-ALA FGS in a human patient, major strides have been
made in its practical applications, leading to improved resection outcomes. As FGS is increasingly
incorporated into neurosurgical practice, it holds promise for future innovations. Generouslyillustrated
and enhanced with online videos, this textbook is the definitive resource on the subject.
Key Features
The improved efficacy of 5-ALA for resecting high- and low-grade gliomas, recurrences,
meningiomas, brain metastases, spinal cord tumors, pediatric brain tumors, and other adult tumors
The future of fluorescence, including potentially powerful new fluorophores molecularly targeted
specifically to tumors
The use of the fluorescent agent indocyanine green (ICG) for brain tumors, cerebral aneurysms,
AVMs, and cerebral vascularization
Special topics such as fluorescein, illuminating tumor paint, confocal microscopy, Raman
spectroscopy, and integrating FGS with intraoperative imaging and brain mapping
This single accessible reference presents the current state-of-the-art on this emerging, exciting
surgical technology. As such, it is a must-have for neurosurgical residents, fellows, and practicing
neurosurgeons.
Notizen