Adverse Cutaneous Drug Reactions to Cardiovascular Drugs

Adverse cutaneous drug reactions (ACDR) are among the most frequent events in patients receiving drug therapy. Cardiovascular (CV) drugs are an important group of drugs with potential risk of developing ACDR especially in elderly as marketing of more new drugs and their prescription continue to increase. However, like with most other drugs the exact incidence of cutaneous side effects from CV drugs is difficult to estimate due to sporadic reporting. Moreover, a reliable designation of a certain drug as the cause of a certain type of reaction can rarely be made. Apart from the well-known angioedema/urticaria from ACE inhibitors, lichen planus / lichenoid reaction from beta adrenergic blockers and photosensitivity from thiazid diuretics, ACDR from CV drugs might be seen in a wide spectrum extending to rare but life-threatening conditions such as erythroderma, Stevens-Johnson syndrome, toxic epidermal necrolysis or drug hypersensitivity syndrome. In this comprehensive review, the reported types of ACDR to CV drugs will be discussed according to drug class and the type of dermatologic reaction with special emphasize on cross-reactions and the role of patch testing in diagnosis.

Esen ÖZKAYA: Professor of Dermatology in Istanbul University, Istanbul Medical Faculty, Department of Dermatology and Venereology. EDUCATIONAL AND ACADEMIC BACKGROUND Graduated with the first degree from German High School Istanbul in 1984 and from Istanbul Medical Faculty, Istanbul University in 1990. Resident of Dermatology in Istanbul University, Istanbul Medical Faculty, Department of Dermatology and Venereology (1990-1994). Scholarship resident in Department of Dermatology, WWU (Westfälische Wilhelms Universität) Münster, Germany (1992-1993). Specialist of Dermatology (1994-1998), Associate Professor of Dermatology (1998-2004), and Professor of Dermatology (since 2004) in Istanbul University, Istanbul Medical Faculty, Department of Dermatology and Venereology. ACADEMIC POSITION University teacher in Istanbul University, Istanbul Medical Faculty, Department of Dermatology and Venereology (since 1998). Founder of the Dermatoallergy unit in the Department of Dermatology and Venereology, Istanbul Medical Faculty in 1996. POSTGRADUATE EDUCATIONAL PROJECTS Head of the organizing committee and tutor of the postgraduate training courses of dermatoallergy tests for dermatologists in 2007 (DATK 2007) and in 2009 (DATK 2009) AWARDS German Academic Exchange Service-DAAD scholarship award (1992-1993). Istanbul University Science Award (2003). SCIENTIFIC PUBLICATIONS Approximately 70 publications in peer-reviewed international journals and many articles in national journals mainly on allergic contact dermatitis, adverse cutaneous drug reactions, atopic dermatitis, and urticaria. Author of an upcoming Turkish book on allergic skin diseases and diagnostic tests.

KURTULUS DIDEM YAZGANOGLU: Associate Professor of Dermatology in Istanbul University, Istanbul Medical Faculty, Department of Dermatology and Venereology. EDUCATIONAL AND ACADEMIC BACKGROUND Graduation from Izmir Özel Türk College, Science High School in 1994 and from Ege University Medical Faculty in 2000, Resident of Dermatology (2001-2005), Specialist of Dermatology (2006-2013), and Associate Professor of Dermatology (since 2013) in Istanbul University, Istanbul Medical Faculty, Department of Dermatology and Venereology. ACADEMIC POSITION University teacher in Istanbul University, Istanbul Medical Faculty, Department of Dermatology and Venereology (since 2013). POSTGRADUATE EDUCATIONAL PROJECTS Member of the organizing committee of postgraduate training courses of dermatoallergy tests for dermatologists in 2007 (DATK 2007) and 2009 (DATK 2009). MEMBERSHIPS Turkish Medical Association, Turkish Society of Dermatology. SCIENTIFIC PUBLICATIONS Approximately 25 publications in peer-reviewed international journals and many articles in national journals. Co-author of two previous Springer books, 'Dermatologic Diseases of the Nose and Ears: An Illustrated Guide' and 'Clinical Atlas of Skin Tumors'.